In women on anti-estrogen drugs for breast cancer, the most effective treatment for hot flushes and sweats is sustained-release venlafaxine 75 mg daily. At this dosage, side effects are minimal and over 50% of patients achieve a significant reduction in hot flushes and night sweats. I don't have much experience in using this treatment in men on hormonal suppression therapy, but it's likely to be just as helpful in them. I usually advise my patients to use the drug for six months, then try withdrawing for a few weeks to see whether they still need it -- in many cases, flushing levels off over time. JJ